Abstracts from Peer Reviewed Literature on Coconut Oil and Derivatives
Virgin Coconut Oil
Antioxidant and anti-inflammatory effects of virgin coconut oil supplementation abrogate acute chemotherapy oxidative nephrotoxicity induced by anticancer drug methotrexate in rats.
Biomed Pharmacother. 2017 Dec 7
Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation
Acta Sci Pol Technol Aliment. 2017 Oct-Dec
Angiogenic and wound healing potency of fermented virgin coconut oil: in vitro and in vivo studies.
Am J Transl Res. 2017 Nov 15
Dietary Supplementation with Virgin Coconut Oil Improves Lipid Profile and Hepatic Antioxidant Status and Has Potential Benefits on Cardiovascular Risk Indices in Normal Rats
Journal of Dietary Supplements. 2017 Aug 17
Anti-inflammatory and antioxidant effect of Kerabala: a value-added ayurvedic formulation from virgin coconut oil inhibits pathogenesis in adjuvant-induced arthritis.
Inflammopharmacology. 2016 Nov 22.
Renoprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats.
Appl Physiol Nutr Metab. 2016 Oct
Virgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats.
J Food Sci Technol. 2016 Jan
Virgin coconut oil improves hepatic lipid metabolism in rats–compared with copra oil, olive oil and sunflower oil.
Indian J Exp Biol. 2012 Nov;50(11):802-9.
Virgin coconut oil supplementation prevents bone loss in osteoporosis rat model
Evid Based Complement Alternat Med. 2012;2012:237236. Epub 2012 Sep 16.
An open-label pilot study to assess the efficacy and safety of virgin coconut oil in reducing visceral adiposity.
ISRN Pharmacol. 2011;2011:949686. Epub 2011 Mar 15.
In vivo Antinociceptive and Anti-inflammatory Activities of Dried and Fermented Processed Virgin Coconut Oil
Med Princ Pract. 2011;20(3):231-6. Epub 2011 Mar 29.
Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil
Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 142739
Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil.
Pharm Biol. 2010 Feb;48(2):151-7.
Wet and dry extraction of coconut oil: impact on lipid metabolic and antioxidant status in cholesterol coadministered rats.
Can J Physiol Pharmacol. 2009 Aug;87(8):610-6.
Antioxidant capacity and phenolic acids of virgin coconut oil.
Int J Food Sci Nutr. 2009;60 Suppl 2:114-23. Epub 2008 Dec 27.
Coconut phytocompounds inhibits polyol pathway enzymes: Implication in prevention of microvascular diabetic complications
Prostaglandins Leukot Essent Fatty Acids. 2017 Dec
The Effect of Coconut Oil pulling on Streptococcus mutans Count in Saliva in Comparison with Chlorhexidine Mouthwash.
J Contemp Dent Pract. 2016 Jan
COCONUT OIL: NON-ALTERNATIVE DRUG TREATMENT AGAINST ALZHEIMER´S DISEASE
Nutr Hosp. 2015 Dec 1
An ecological study for Sri Lanka about health effects of coconut.
Ceylon Med J. 2015 Sept
Aluminum phosphide poisoning: Possible role of supportive measures in the absence of specific antidote
Indian J Crit Care Med. 2015 Feb; 19
Coconut Oil Attenuates the Effects of Amyloid-β on Cortical Neurons In Vitro.
J Alzheimers Dis. 2013 Oct 22.
Dietary fatty acids and oxidative stress in the heart mitochondria.
Mitochondrion. 2010 Aug 5.
In vitro antimicrobial properties of coconut oil on Candida species in Ibadan, Nigeria.
J Med Food. 2007 Jun;10(2):384-7.
Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation.
Clin Biochem. 2004 Sep;37(9):830-5.
A diet rich in coconut oil reduces diurnal postprandial variations in circulating tissue plasminogen activator antigen and fasting lipoprotein (a) compared with a diet rich in unsaturated fat in women.
J Nutr. 2003 Nov;133(11):3422-7.
COCONUT OIL: Atherogenic or Not?
(What therefore causes Atherosclerosis?)
By Conrado S. Dayrit, MD. FACC. FPCC. FPCP
Philippine Journal Of CARDIOLOGY
July-September 2003, Volume 31 Number 3:97-104
Dietary coconut oil increases conjugated linoleic acid-induced body fat loss in mice independent of essential fatty acid deficiency.
Biochim Biophys Acta. 2005 Oct 15;1737(1):52-60. Epub 2005 Sep 13.
Successful treatment of acute aluminium phosphide poisoning: possible benefit of coconut oil.
Hum Exp Toxicol. 2005 Apr;24(4):215-8.
Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studies.
Am J Clin Nutr 1981 Aug;34(8):1552-61
Choice of cooking oils–myths and realities.
J Indian Med Assoc 1998 Oct;96(10):304-7
The role of coconut and coconut oil in coronary heart disease in Kerala, south India.
Trop Doct. 1997 Oct;27(4):215-7.
Coconut oil compound may treat STDs
AIDS Patient Care STDS 1999 Sep;13(9):572
Chirurg 2002 Apr;73(4):387-92
Coconut oil used in Indonesia for treatment of wounds and to preserve medicinal herbs
Energy restriction with high-fat diet enriched with coconut oil gives higher UCP1 and lower white fat in rats.
Int J Obes Relat Metab Disord. 1998 Oct;22(10):974-9.
Intestinal adaptation in short bowel syndrome without tube feeding or home parenteral nutrition: report of four consecutive cases.
Nutrition. 1998 Jun;14(6):508-12.
Coconut Oil and Skin
The effect of topical virgin coconut oil on SCORAD index, transepidermal water loss, and skin capacitance in mild to moderate pediatric atopic dermatitis: a randomized, double-blind, clinical trial.
Int J Dermatol. 2013 Dec 10.
Development and Anti-microbial Potential of Topical Formulations Containing Cocos nucifera Linn.
Antiinflamm Antiallergy Agents Med Chem. 2013 Jun 4
Effect of topical application of virgin coconut oil on skin components and antioxidant status during dermal wound healing in young rats.
Skin Pharmacol Physiol. 2010;23(6):290-7. Epub 2010 Jun 3.
Oil massage in neonates: an open randomized controlled study of coconut versus mineral oil.
Indian Pediatr. 2005 Sep;42(9):877-84.
Uptake of vitamin E succinate by the skin, conversion to free vitamin E, and transport to internal organs.
Biochem Mol Biol Int. 1999 Mar;47(3):509-18.
Coconut Oil and Hair
Clinical trial showing superiority of a coconut and anise spray over permethrin 0.43% lotion for head louse infestation
Eur J Pediatr. 2010 Jan;169(1):55-62.
Effect of mineral oil, sunflower oil, and coconut oil on prevention of hair damage.
J Cosmet Sci. 2003 Mar-Apr;54(2):175-92
Secondary ion mass spectrometric investigation of penetration of coconut and mineral oils into human hair fibers: Relevance to hair damage
J Cosmet. Sci., 52, 169-184 (May/June 2001)
High-fat diets rich in saturated fat protect against azoxymethane/dextran sulfate sodium-induced colon cancer.
Am J Physiol Gastrointest Liver Physiol. 2016 Jun
Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis
Open Heart, BMJ Publishing Group Limited 9 February 2015
Saturated fat is not the major issue
British Medical Journal, 2013 October 22, 347:f6340
Dietary Fats and Health: Dietary Recommendations in the Context of Scientific Evidence
Advances in Nutrition, 2013 May 1;4(3):294-302
Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease.
American Journal of Clinical Nutrition, 2010 Mar;91(3):535-46.
Food Choices and Coronary Heart Disease: A Population Based Cohort Study of Rural Swedish Men with 12 Years of Follow-up
Int. J. Environ. Res. Public Health 2009, 6, 2626-2638
Saturated fat prevents coronary artery disease? An American paradox
American Journal of Clinical Nutrition, Vol. 80, No. 5, 1102-1103, November 2004
Results of use of metformin and replacement of starch with saturated fat in diets of patients with type 2 diabetes.
Endocr Pract 2002 May-Jun;8(3):177-83
Dietary fat intake and risk of stroke in male US healthcare professionals: 14 year prospective cohort study.
BMJ. 2003 Oct 4;327(7418):777-82
The lauric acid-activated signaling prompts apoptosis in cancer cells
Cell Death Discovery, 2017 Sep 18
Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats.
Basic Clin Pharmacol Toxicol. 2016 Nov 7
In Vitro Anti-Propionibacterium Activity by Curcumin Containing
“Our results highlight the potential of using vehicles containing lauric acid and curcumin as an alternative treatment for acne vulgaris.”
Chemical and Pharmaceutical Bulletin (Tokyo). 2013;61(4):419-25.
Effect of saturated fatty acid-rich dietary vegetable oils on lipid profile, antioxidant enzymes and glucose tolerance in diabetic rats.
Indian J Pharmacol. 2010 Jun;42(3):142-5.
Glycerol monolaurate inhibits Candida and Gardnerella vaginalis in vitro and in vivo but not Lactobacillus.
Antimicrob Agents Chemother. 2010 Feb;54(2):597-601
Antibacterial study of the medium chain fatty acids and their 1-monoglycerides: individual effects and synergistic relationships.
Pol J Microbiol. 2009;58(1):43-7.
Glycerol monolaurate prevents mucosal SIV transmission.
Nature. 2009 Apr 23;458(7241):1034-8.
Antimicrobial activity of potassium hydroxide and lauric acid against microorganisms associated with poultry processing.
J Food Prot. 2006 Jul;69(7):1611-5.
Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men.
Peptides. 2006 Jul;27(7):1638-43. Epub 2006 Mar 23.
Glycerol monolaurate inhibits virulence factor production in Bacillus anthracis.
Antimicrob Agents Chemother. 2005 Apr;49(4):1302-5.
Consumption of a Solid Fat Rich in Lauric Acid Results in a More Favorable Serum Lipid Profile in Healthy Men and Women than Consumption of a Solid Fat Rich in trans-Fatty Acids
Journal of Nutrition. 2001;131:242-245
Effect of fatty acids on arenavirus replication: inhibition of virus production by lauric acid
Arch Virol 2001;146(4):777-90
Lauric acid inhibits the maturation of vesicular stomatitis virus.
J Gen Virol. 1994 Feb;75 ( Pt 2):353-61.
MCTs (Medium Chain Triglycerides)
Anti-bacterial and anti-inflammatory properties of capric acid against Propionibacterium acnes: A comparative study with lauric acid.
J Dermatol Sci. 2013 Nov 7. pii: S0923-1811
Caprylic Triglyceride as a Novel Therapeutic Approach to Effectively Improve the Performance and Attenuate the Symptoms Due to the Motor Neuron Loss in ALS Disease
PLoS ONE 7(11): e49191. doi:10.1371/journal.pone.0049191 (2012)
Sophorolipid production by Candida bombicola on oils with a special fatty acid composition and their consequences on cell viability.
Biotechnol Lett. 2010 Oct;32(10):1509-14
Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids.
Diabetes. 2010 May;59(5):1283.
Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia.
Diabetes. 2009 May;58(5):1237-44.
Effect of ingestion of medium-chain triacylglycerols on moderate- and high-intensity exercise in recreational athletes.
J Nutr Sci Vitaminol (Tokyo). 2009 Apr;55(2):120-5.
Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. (Applies to Alzheimer’s)
Neurobiol Aging. 2004 Mar;25(3):311-4.
Medium-Chain Oil Reduces Fat Mass and Down-regulates Expression of Adipogenic Genes in Rats.
Obes Res. 2003 Jun;11(6):734-44.
Protective effects of medium-chain triglycerides on the liver and gut in rats administered endotoxin.
Ann Surg. 2003 Feb;237(2):246-55.
Medium-chain triglycerides increase energy expenditure and decrease adiposity in overweight men.
Obes Res. 2003 Mar;11(3):395-402.
Larger diet-induced thermogenesis and less body fat accumulation in rats fed medium-chain triacylglycerols than in those fed long-chain triacylglycerols.
J Nutr Sci Vitaminol (Tokyo). 2002 Dec;48(6):524-9.
Comparison of diet-induced thermogenesis of foods containing medium- versus long-chain triacylglycerols.
J Nutr Sci Vitaminol (Tokyo). 2002 Dec;48(6):536-40.
Enteral nutrition in Crohn’s disease: fat in the formula.
Eur J Gastroenterol Hepatol. 2003 Feb;15(2):115-8.
Protective effects of medium-chain triglycerides on the liver and gut in rats administered endotoxin.
Ann Surg. 2003 Feb;237(2):246-55.
The influence of a preserved colon on the absorption of medium chain fat in patients with small bowel resection.
Gut. 1998 Oct;43(4):478-83.
Killing of Gram-positive cocci by fatty acids and monoglycerides
APMIS 2001 Oct;109(10):670-8
Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity.
J Nutr 2002 Mar;132(3):329-32
Value of VLCD supplementation with medium chain triglycerides
Int J Obes Relat Metab Disord 2001 Sep;25(9):1393-400
In vitro killing of Candida albicans by fatty acids and monoglycerides.
Antimicrob Agents Chemother 2001 Nov;45(11):3209-12
Decreased fat and nitrogen losses in patients with AIDS receiving medium-chain-triglyceride-enriched formula vs those receiving long-chain-triglyceride-containing formula.
Am Diet Assoc. 1997 Jun;97(6):605-11
Effects of different lipid sources in total parenteral nutrition on whole body protein kinetics and tumor growth.
JPEN J Parenter Enteral Nutr. 1992 Nov-Dec;16(6):545-51
Enhanced thermogenesis and diminished deposition of fat in response to overfeeding with diet containing medium chain triglyceride.
Am J Clin Nutr. 1982 Apr;35(4):678-82
Thermogenesis in humans during overfeeding with medium-chain triglycerides.
Metabolism. 1989 Jul;38(7):641-8